The Chagas Disease Foundation

Chagas disease is a debilitating and often fatal disease resulting from infection with the protozoan parasite Trypanosoma cruzi. The infection affects up to 20 million people in Mexico, Central America, and South America, making Chagas disease the highest impact infectious disease in Latin America. In addition to being a disease of poverty, Chagas disease is also poverty-promoting in striking hardest in young adults. Chagas disease has recently gained some notoriety in the United States due to both endogenous ("home-grown") and imported cases, prompting concern about the safety of blood and organ/tissue donations. Although 2009 marks the 100 year anniversary of the discovery of Chagas disease, the diagnosis, treatment and prevention of this infection are all highly inadequate. The battle against Chagas disease begins with information and education. More about Chagas Disease

Chagas Research Worldwide

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The Chagas Research Map Repository seeks to catalog global research efforts on Chagas disease. Use the orientation tools to identify sites in particular areas, or launch the full map and use search terms to find sites of interest. Browse individual research groups to learn more about their interests and needs.

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Research Spotlight

Sterol Biosynthesis Inhibitors for Chagas Disease
University of Washington
Seattle, United States

We are optimizing three structural series of inhibitors of lanosterol-14alpha-demethylase (Cyp51) as anti-T. cruzi agents for the treatment of Chagas disease.

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News

New compound shows promise in treating Chagas' disease - Examiner.com

'Piranha 3D' unfair to the fish - msnbc.com (blog)

A Creative Model for Vaccine Development - Forbes (blog)

Identified compound can seemingly help fight Chagas' disease - HealthJockey.com

The role of the rheumatoid factor - Irish Medical Times

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Recent Studies

Review on Trypanosoma cruzi: Host Cell Interaction.
de Souza W, de Carvalho TM, Barrias ES

Infectivity, Pathogenicity, and Virulence of Trypanosoma cruzi Isolates from Sylvatic Animals and Vectors, and Domestic Dogs from the United States in ICR Strain Mice and SD Strain Rats.
Roellig DM, Yabsley MJ

T-bet-independent effects of IL-12 family cytokines on regulation of Th17 responses to experimental T. cruzi infection.
Cobb D, Hambright D, Smeltz RB

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