The Chagas Disease Foundation

Website Research Map

Chagas disease is a debilitating and often fatal disease resulting from infection with the protozoan parasite Trypanosoma cruzi. The infection affects up to 20 million people in Mexico, Central America, and South America, making Chagas disease the highest impact infectious disease in Latin America. In addition to being a disease of poverty, Chagas disease is also poverty-promoting in striking hardest in young adults. Chagas disease has recently gained some notoriety in the United States due to both endogenous ("home-grown") and imported cases, prompting concern about the safety of blood and organ/tissue donations. Although 2009 marks the 100 year anniversary of the discovery of Chagas disease, the diagnosis, treatment and prevention of this infection are all highly inadequate.  The battle against Chagas disease begins with information and education.    More about Chagas Disease

Chagas Research Worldwide

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The Chagas Research Map Repository seeks to catalog global research efforts on Chagas disease.  Use the orientation tools to identify sites in particular areas, or launch the full map and use search terms to find sites of interest.  Browse individual research groups to learn more about their interests and needs.

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Research Spotlight

Antibiotics for Chagas Disease

Athens, United States

My research interest is in the design and synthesis of new drug candidates for Chagas Disease.

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Recent Studies

Trypanosoma cruzi Infection Down-Modulates the Immunoproteasome Biosynthesis and the MHC Class I Cell Surface Expression in HeLa Cells.
Camargo R, Faria LO, Kloss A, Favali CB, Kuckelkorn U, Kloetzel PM, de Sá CM, Lima BD

In vitro and In vivo Biological Effect of Novel Arylimidamide Derivatives Against Trypanosoma cruzi.
Timm BL, Bernardino da Silva P, Batista MM, Guedes da Silva FH, da Silva CF, Tidwell RR, Patrick DA, Kilgore Jones S, Bakunov SA, Bakunova SM, Soeiro MD

Optimization of Anti-trypanosomatid Agents: Identification of Non-Mutagenic Drug Candidates with in vivo Activity.
Alvarez G, Varela J, Márquez P, Gabay M, Arias Rivas CE, Cuchilla K, Echeverría GA, Piro OE, Chorilli M, Leal SM, Escobar P, Serna E, Torres S, Yaluff G, Vera de Bilbao NI, González M, Cerecetto H

Mesenchymal stromal cells mediate Aspergillus hyphal extract-induced allergic airway inflammation by inhibition of the Th17 signaling pathway.
Lathrop MJ, Brooks EM, Bonenfant NR, Sokocevic D, Borg ZD, Goodwin M, Loi R, Cruz F, Dunaway CW, Steele C, Weiss DJ

Assessment of the anti-protozoal activity of crude Carica papaya seed extract against Trypanosoma cruzi.
Jiménez-Coello M, Guzman-Marín E, Ortega-Pacheco A, Perez-Gutiérrez S, Acosta-Viana KY

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