The Chagas Disease Foundation

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Chagas disease is a debilitating and often fatal disease resulting from infection with the protozoan parasite Trypanosoma cruzi. The infection affects up to 20 million people in Mexico, Central America, and South America, making Chagas disease the highest impact infectious disease in Latin America. In addition to being a disease of poverty, Chagas disease is also poverty-promoting in striking hardest in young adults. Chagas disease has recently gained some notoriety in the United States due to both endogenous ("home-grown") and imported cases, prompting concern about the safety of blood and organ/tissue donations. Although 2009 marks the 100 year anniversary of the discovery of Chagas disease, the diagnosis, treatment and prevention of this infection are all highly inadequate.  The battle against Chagas disease begins with information and education.    More about Chagas Disease

Chagas Research Worldwide

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The Chagas Research Map Repository seeks to catalog global research efforts on Chagas disease.  Use the orientation tools to identify sites in particular areas, or launch the full map and use search terms to find sites of interest.  Browse individual research groups to learn more about their interests and needs.

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Research Spotlight

Immunobiology of Chagas Disease
UGA - Tarleton Lab
Athens, United States

We are broadly interested in immunity to Trypanosoma cruzi, and particularly in the role of CD8+ T cells in control of this infection. Other interests include development of improved diagnostics and methods for assessing treatment efficacy, vaccine development, and genomic, proteomic, transcriptomic and bioinformatic approaches to better understanding the biology of T. cruzi and combating Chagas disease.

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Recent Studies

Effect of secondary anchor amino acid substitutions on the immunogenic properties of an HLA-A*0201-restricted T cell epitope derived from the Trypanosoma cruzi KMP-11 protein.
Lasso P, Cárdenas C, Guzmán F, Rosas F, Thomas MC, López MC, González JM, Cuéllar A, Campanera JM, Luque FJ, Puerta CJ

Phthalimido-thiazoles as building blocks and their effects on the growth and morphology of Trypanosoma cruzi.
Gomes PA, Oliveira AR, Cardoso MV, Santiago EF, Barbosa MO, de Siqueira LR, Moreira DR, Bastos TM, Brayner FA, Soares MB, Mendes AP, de Castro MC, Pereira VR, Leite AC

Aberrant levels of Wnt/β-catenin pathway components in a rat model of endometriosis.
de Mattos RM, Pereira PR, Barros EG, da Silva JH, Palmero CY, da Costa NM, Pinto LF, Gimba ER, Medeiros FH, Ferreira LB, Machado DE, de Oliveira FL, Nasciutti LE

Inactivated poliovirus vaccine given alone or in a sequential schedule with bivalent oral poliovirus vaccine in Chilean infants: a randomised, controlled, open-label, phase 4, non-inferiority study.
O'Ryan M, Bandyopadhyay AS, Villena R, Espinoza M, Novoa J, Weldon WC, Oberste MS, Self S, Borate BR, Asturias EJ, Clemens R, Orenstein W, Jimeno J, Rüttimann R, Costa Clemens SA, Chilean IPV/bOPV study group

Intranasal vaccination with leishmanial antigens protects golden hamsters (Mesocricetus auratus) against Leishmania (Viannia) Braziliensis infection.
da Silva-Couto L, Ribeiro-Romão RP, Saavedra AF, da Silva Costa Souza BL, Moreira OC, Gomes-Silva A, Rossi-Bergmann B, Da-Cruz AM, Pinto EF

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